C-Telopeptide Pyridinoline Cross-Links
Identifieur interne : 009217 ( Main/Exploration ); précédent : 009216; suivant : 009218C-Telopeptide Pyridinoline Cross-Links
Auteurs : William V. GiannobileSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 1999.
Abstract
C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.
Url:
PubMed: 10415744
PubMed Central: 2586930
Affiliations:
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Le document en format XML
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